Hatem E. Sabaawy, MD, PhD
Director of Production GMP Facility for Cell and Gene Therapy
Cancer Institute of New Jersey
Phone: (732) 235-8081
Assistant: Audrea Henry
Research Program Alignment
Membership Type: Full
- Studying the leukemogenic effects of oncogenic fusion proteins that involve TEL (Also called ETV6) and AML1 (Also called RUNX1) hematopoietic transcription factors. Both TEL and AML1 are early transcription factors commonly involved in chromosomal rearrangements in many cancers. The two long-term goals of our research program are to define the transcriptional effects of TEL and AML1 on lineage commitment, and to identify the leukemic stem cell and the transformation events associated with TEL-AML1 leukemias
- Another focus is translational research studies of normal stem cell development and plasticity, and the development of a closed system separation of stem cells for cell therapy applications in regenerative medicine.
Sabaawy HE, Farouk I, Gaafar T, and N Afifi. Study of PCR-amplified t(14; 18) chromosomal breakpoints in Non-Hodgkin’s lymphoma. NCI Proceedings 1995; 11: 146-52.
Sabaawy HE, Farley T, Ahmed T, Feldman E , and NG Abraham. Combined therapeutic effectiveness of retrovirus-mediated interferon-α gene transfer and 5-FU on colon cancer cells. Acta Hematol 1999; 101:82-8.
Sabaawy HE, Ikehara S, Adachi Y, Quan S, Feldman E, Kancherla R, Abraham NG, and T Ahmed. Enhancement of 5-fluorouracil cytotoxity on human colon cancer cells by retrovirus-mediated interferon-α gene*. International journal of Oncology 1999; 14: 1143-51.*The Winner of Current Awareness in Biomedicine: Gene Therapy publication, 1999.
da Silva JL, Zand BA, Yang LM, Sabaawy HE, Lianos E, and NG Abraham. Heme Oxygenase isoform-specific expression and distribution in the rat kidney. Kidney International 2001; 59: 1448-57.
Sabaawy HE, Zhang F, Nasjletti A, Schwartzman M, and NG Abraham. Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats. Hypertension 2001; 38(2): 210-5.
Sacerdoti D, McGiff J, Oyeken A, Yang L, Sabaawy HE, A. Gatta A. and NG Abraham. Transfection of rats with human Heme-Oxygenase-1 gene reproduces abnormalities of the mesenteric circulation of cirrhosis. Journal of Hepatology 2002; 34 (Supp.l): 13-19.
Sabaawy HE, and E Farouk. Transplantation of Human Mesenchymal Progenitor Cells in Chronic Myeloid Leukemia. ESLM Proceedings 2002; 4: 28-32.
Pine S, Yin C, Matloob Y, Sabaawy H, Sandoval C, Levendoglu-Tugal O, Ozkaynak M, and S. Jaybose. Quantitative real-time PCR detection of Occult CNS-Leukemia in children with acute lymphoblastic leukemia. Journal of Molecular Diagostics 2005; 7: 127-32.
Sabaawy HE, Azuma M, Embree L, Tsai HJ, Starost MF, and DD Hickstein. TEL-AML1 transgenic zebrafish model of precursor B-cell acute lymphoblastic leukemia. Proceedings of the National Academy of Science, USA 2006; 103: 15166-15171.
Sabaawy HE, Yin C, Sandoval C, Levendoglu-Tugal O, Wormser G, Jaybose S, and S. Pine. Lymphoproliferative clonal origin of AIDS-related Non-Hodgkin's lymphoma. Leukemia and Lymphoma 2007; 48: 812-815.
Azuma M, Embree L, Sabaawy HE, and DD Hickstein. Ewing’s sarcoma protein Ewsr1 maintains mitotic integrity and proneuronal survival in the zebrafish embryos. PloSOne 2007; 2 (10): e979.
Yu YM, Gibbs KM, Davila J, Campbell N, Sung S, Todorova TI, Otsuka S, Sabaawy HE, Hart RP, and Schachner M. MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish. European Journal of Neuroscience, 2011; 4: 1-11. PMID: 21447094.
Patel N, Klassert TE, Greco SJ, Patel SA, Reddy BY, Bryan M, Campbell N, Kokorina NA, Sabaawy HE*, and Rameshwar P. Developmental activation pathways in TAC1 expression in human mesenchymal stem cells-derived peptidergic neurons for the repair of spinal cord injury in zebrafish. Stem Cells and Development, 2012; 21(2): 308-320. PMID: 21671725. * Corresponding author. [Cover illustration].
Kramer J, Granier C, Marshall S, Piso K, Hand J, Rabson A, and Sabaawy HE. PDCD2 controls hematopoietic stem cell differentiation during development. Stem Cells and Development, 2012 Jul 16. [Epub ahead of print] PMID: 22800338.
El Ansary M, Mogawer S, Elhamid SA, Alwakil S, Aboelkasem F, Sabaawy HE*, Abdelhalim O. Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC. Journal of Cancer Research Clinical Oncology. 2012 Aug 12. [Epub ahead of print] PMID:22886490. *Corresponding author.
Kokorina NA, Granier C, Zakharkin SO, Marshall S, Rabson A, and Sabaawy HE. PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells. Experimental Hematology 2012 Aug 21. [Epub ahead of print] PubMed PMID: 22922207.
Bansal N, Marshall S, Cao L, Sydorenko N, Moon YC, Sindhu TS, Rafanan M, Jeganathan G, Budak-Alpdogan T, Stein MN, Kim IY, Medina DJ, Davis TW, DiPaola RS, Bertino JR, and Sabaawy, HE. Development of inhibitors targeting Bmi-1 in human prostate tumor-initiating cells. Cancer Discovery (Revised manuscript under second peer review).
Elkheir WA, Gabr H, Awad R, Ghannam O, Barakat Y, Farghali H, El Maadawi Z, Ewes I, and HE Sabaawy. Autologous adherent BM-derived cell therapy combined with physical therapy induces partial recovery in chronic spinal cord injury patients. Cell Transplantation (Accepted with minor revision).Gabr H, Elkheir WA, Farghali H, Ismail ZMK, Zickri MB, El Maadawi Z, Kishk NA, and HE Sabaawy. Intrathecal transplantation of autologous adherent bone marrow cells induces functional neurological recovery in a canine model of spinal cord injury. Cell Transplantation (Accepted with minor revision).