Researcher Profile

Paul R. Copeland, PhD

Graduate Program Director Microbiology and Molecular Genetics at Robert Wood Johnson Medical School
Associate Professor of Biochemistry and Molecular Biology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

RWJMS Research Tower
675 Hoes Lane West, Room 738
Piscataway, NJ 08854

Phone: (732) 235-4670

Research Program Alignment

Membership Type: Full

Research Interests

  • Selenium
  • Protein Synthesis
  • Male Contraception
  • Translation Elongation
  • Ribsome
  • Selenocysteine
  • RNA

Selected Publications

Frolova, E.I., Dolganov, G.M.,. Mazo, I.A., Smirnov, D.V. Copeland, P. Stewart, C., O'Brien S. J., and Dean M. (1991) Linkage mapping of the human CSF2 and IL3 genes. Proc Natl Acad Sci 88: 4821-4.

Copeland, P.R. and D.M. Driscoll (1999). Purification, redox sensitivity and RNA binding properties of SECIS-binding protein 2, a protein involved in selenoprotein biosynthesis. J. Biol Chem 274: 25447-25454.

Copeland, P.R., Fletcher, J.E. Carlson, B.A.. Hatfield, D.L. and Driscoll, D.M (2000). A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. EMBO J. 19:306-314.

Tujebajeva, R. M., Copeland, P.R., Xu, X-M., Carlson, B.A., Harney, J.W., Driscoll, D.M. Hatfield, D.L. and Berry, M.J. (2000) Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Reports 1:158-163.

Fletcher, J.E., Copeland, P.R. and Driscoll, D.M. (2000) Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: Evidence for a block in elongation at the UGA/selenocysteine codon. RNA 6:1573-1584.

Copeland, P.R., Stepanik, V.A., and Driscoll, D.M. (2001) Insights into mammalian selenocysteine incorporation: Domain structure and ribosome binding of SBP2. Mol. Cell. Biol. 21:1491-1498.

Copeland, P.R. and Wormington, M. (2001) The mechanism and regulation of deadenlyation: Identification and characterization of Xenopus PARN. RNA 7:875-886.

Fletcher, J.E., Copeland, P.R. Driscoll, D.M., Krol, A. (2001). RNA Footprinting analysis of SBP2/SECIS interactions. RNA, 7:1442-1453.

Copeland, P.R. and Driscoll, D.M. (2001) SECIS binding proteins. In: Selenium: Its Molecular Biology and Role in Human Health (D.L. Hatfield, ed.), Kluwer Academic Publishers, pp 55-68.

Copeland, P.R. and Driscoll, D.M. (2001) RNA binding proteins and selenocysteine. Biofactors, 14:11-14.

Berry MJ, Tujebajeva RM, Copeland PR, Xu XM, Carlson BA, Martin GW 3rd, Low SC, Mansell JB, Grundner-Culemann E, Harney JW, Driscoll DM, Hatfield DL. (2001) Selenocysteine incorporation directed from the 3'UTR: characterization of eukaryotic EFsec and mechanistic implications. Biofactors. 14(1-4):17-24.

Copeland, P.R. and Driscoll, D.M. (2002) Identification of Selenoprotein mRNA Binding Proteins. In: Protein Sensors of Reactive Oxygen Species: Selenoproteins, Thioredoxin, Thiol Enzymes and Proteins, Methods Enzymol., 347:40-49.

Driscoll, D.M. and Copeland, P.R. (2003). Mechanism and regulation of selenoprotein synthesis. Ann Rev Nutr. 23:17-40.

Copeland, P.R. (2003). Regulation of gene expression by stop codon recoding: selenocysteine. Gene. 312:17-25

Mehta, A., Rebsch, C.M., Kinzy, S.A., Fletcher, J.E. and Copeland P.R. (2004) Efficiency of Mammalian Selenocysteine Incorporation. J. Biol. Chem. 279:37852-59.

The content for this Research Profile is maintained by Paul Novembre (