Fumio Matsumura, PhD Professor of Molecular Biology and Biochemistry Rutgers, The State University of New Jersey Nelson Biology Laboratories 604 Allison Road, Room A321 Piscataway, NJ 08855 Phone: (732) 445-2838 Email: matsumura@biology.rutgers.edu

Research Program Alignment

• Genomic Instability and Tumor Progression Program

Membership Type: Full

Selected Publications

Yamashiro, S. Yamakita Y., Ishikawa, R., and Matsumura, F. Mitosis-specific phosphorylation causes 83kDa nonmuscle caldesmon to dissociate from microfilaments. Nature 344, 675-678, 1990.

Yamashiro, S. and Yamakita, Y., Hosoya, H., and Matsumura F. Phosphorylation of nonmuscle caldesmon by p34cdc2 kinase during mitosis. Nature 349, 169-172, 1991.

Matsumura, F., Ono, S., Yamakita, Y., Totsukawa, G., and Yamashiro, S. Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells. J. Cell Biol. 140: 119-129. 1998.

Totsukawa, G., Yamakita, Y., Yamashiro, S., Hosoys, H., Hartshorne, D. H., and Matsumura, F. Activation of myosin phosphatase targeting subunit by mitosis-specific phosphorylation. J. Cell Biol. 144:735-744. 1999. PMCID: PMC2132942

Totsukawa G., Wu, Y., Sasaki, Y., Hartshorne, D. J., Yamakita Y., Yamashiro, S. and Matsumura, F. Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J. Cell Biol. 164: 427-439. 2004. PMCID: PMC2172229

Matsumura, F., Regulation of myosin II during cytokinesis in higher eukaryotes. TRENDS in Cell Biology. 15:371-377. 2005.

Matsumura, F. & Hartshorne, D. Myosin phosphatase targeting subunit: Many roles in cell function. BBRC. 369:149-156. 2008. PMCID: PMC2367208

Yamashiro, S., Yamakita, Y., Totsukawa, G., Goto, H., Kaibuchi, K., Ito, M., Hartshorne, D. and Matsumura, F. Myosin phosphatase targeting subunit1 regulates mitosis by antagonizing pololike kinase1. Dev. Cell 14:787-797. 2008. PMCID: PMC2680213

M. Asiedu, D. Wu, F. Matsumura, and Q. Wei Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle. J. Biol. Chem., 283:28392-28400, 2008. PMCID: PMC2568926

M. Asiedu, D. Wu, F. Matsumura, and Q. Wei Centrosome/spindle pole-associated protein (CSPP) regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Molecular Biology of Cell, 20(5):1428-40. 2009. PMCID: PMC2649278

Yamakita, Y., Matsumura, F., and Yamashiro, S. Fascin1 is dispensable for mouse development but is favorable for neonatal survival. Cell Motility and the Cytoskeleton, 66(8):524-534. 2009. PMCID: PMC2738588

Sedeh, R.S., A.A. Fedorov, E.V. Fedorov, S. Ono, F. Matsumura, S.C. Almo, and M. Bathe. Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. J Mol Biol. 400:589-604. 2010.

Pal, D., D. Wu, A. Haruta, F. Matsumura, and Q. Wei. Role of a novel coiled-coil domaincontaining protein CCDC69 in regulating central spindle assembly. Cell Cycle. 9:4117-29. 2010.

Yamakita, Y., F. Matsumura, M.W. Lipscomb, P.C. Chou, G. Werlen, J.K. Burkhardt, and S. Yamashiro. Fascin1 Promotes Cell Migration of Mature Dendritic Cells. J Immunol. 186: 2850-9. 2011.

Matsumura, F., Y. Yamakita, and S. Yamashiro. Myosin phosphatase targeting subunit1 controls chromatid segregation. J Biol Chem. 286: 10825-10833. 2011. PMCID: PMC3060533

Matsumura, F., Yamakita, Y., and Yamashiro, S., Myosin light chain kinases and phosphatase in mitosis and cytokinesis. Arch Biochem Biophys, 510:76-82. 2011.