The availability of high throughput data has created the exciting new field of systems biology which is changing the face of clinical care and leading to new advances in our understanding of the genetic and molecular underpinnings of phenotypic diversity and disease processes. My lab is focused on developing algorithms to extract novel information from such data sets. In cancer biology, we are trying to identify find biomarkers and biological mechanisms which pinpoint dysregulated pathways and mechanisms with the goal of developing panels for clinical risk profiling, identifying pharmaceutically relevant drug targets and improving clinical care. We work closely with surgeons and clinical oncologists in several hospitals in the US and abroad to ensure that our research is always focused on the patient and is relevant to improving clinical outcome. In population genetics, we are trying to understanding the interplay of selection, adaptation and population dynamics and the role of polymorphisms in complex disease processes and in the interconnected evolution of diverse organisms from viruses to mammals.