Researcher Profile

Celine Gelinas, PhD

Associate Dean for Research, RWJMS; Resident Faculty, Center for Advanced Biotechnology and Medicine
Professor of Biochemistry and Molecular Biology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Center for Advanced Biotechnology and Medicine
679 Hoes Lane West, Room 137
Piscataway, NJ 08854-5638

Phone: (732) 235-5035
Email: gelinace@rwjms.rutgers.edu

Assistant: Elaine Simpson
(732) 235-5578
Email: simpson@cabm.rutgers.edu

Research Program Alignment

Membership Type: Associate


Research Interests

  • Cancer
  • Apoptosis
  • Transcription Factors
  • Gene Expression
  • Oncogenes

Selected Publications

Rayet, B., Fan, Y. and Gélinas, C. (2003) Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kB-regulated cell death inhibitors important for v-Rel transforming activity. Mol. Cell. Biol. 23: 1520-1533.

Edelstein, L.C., Lagos, L., Simmons, M., Tirumalai, H. and Gélinas, C. (2003) NF-kB-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. Mol. Cell. Biol. 23: 2749-2761.

Fan, Y., Rayet, B. and Gélinas, C. (2004) Divergent C-terminal transactivation domains of Rel/NF-kB proteins are critical determinants of their oncogenic potential. Oncogene 23: 1030-1042.

Kucharczak, J.F., Simmons, M.J., Duckett, C.S. and Gélinas, C. (2005) Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a pro-death factor. Cell Death & Differ. 12: 1225-1239.

Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson A, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson D, Jin S and White E. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 10: 51-64.

Pegman, P.M., Smith, S.M., D'Souza, B.N., Loughran, S.T., Maier, S, Kempkes, B., Cahill, P.A., Simmons, M.J., Gélinas, C. and Walls, D.. (2006) The Epstein-Barr virus nuclear antigen 2 trans-activates the cellular anti-apoptotic bfl-1 gene by a CBF-1/RBPJ dependent pathway. J. Virol. 80: 8133-8144.

Fan Y, Gélinas C (2007) An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation Oncogene 26: 4038-4043.

Gupta N, Delrow J, Drawid, A, Sengupta AM, Fan G and Gélinas C. (2008) Repression of BLNK and BCAP is important for lymphocyte transformation by Rel proteins. Cancer Research 68: 808-814.

Simmons, M.J, Fan G, Zong, W.X., Degenhardt K, White E and Gélinas C. (2008) Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene 27: 1421-1428.

Dutta J, Fan G and Gélinas C. (2008) CAPERa is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kB oncoprotein v-Rel. J. Virol. 82: 10792-10802.

Mathew R, Karp C, Beaudoin B, Vuong N, Chen G, Chen H-Y, Bray K, Reddy A, Bhanot G, Gelinas C, DiPaola RS, Karantza-Wadsworth V, White E. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.

Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhen Zhou X, Lu KP and Gélinas C. (2009) Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the Rel proteins in the NF-kB family.Cancer Research 69: 4589-4597.

Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E and Gélinas C. (2010) Defective ubiquitin-mediated degradation of anti-apoptotic Bfl-1 predisposes to lymphoma. Blood 115: 3559-3569.

Guo JY, Chen H-Y, Mathew R, Fan J, Strohecker AM, Kamphorst JJ, Chen G, Lemmons JMS, Karantza V, Coller HA, DiPaola RS, Gélinas C, Rabinowitz JD and White E. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Dev. 25: 460-470.

Medina DJ, Goodell L, Glod J, Gélinas C, Rabson AB and Strair RK. (2012) Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor B pathways. Hematologica 97:1255-63.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)