Karine A. Cohen-Solal, PhD

Assistant Professor of Medicine, Medical Oncology
Robert Wood Johnson Medical School

Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-8512
Email: cohenska@umdnj.edu

Assistant: Joyce Beverley
(732) 235-7006
Email: beverljm@umdnj.edu

Research Program Alignment

• Cell Death and Survival Signaling Program

Membership Type: Full

Selected Publications

Cohen-Solal, K., Reuhl, K. R., Ryan, K. B., Roberts, K. G. And Chen, S.Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. Pigment Cell Research (2001) 14, 466-474.

Cohen-Solal, K., Crespo-Carbone, S.M., Namkoong, J., Mackason, K. R., Roberts, K. G, Reuhl, K. R. And Chen, S. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Research (2002) 15, 282-289.

Pollock, P., Cohen-Solal, K., Sood, R., Namkoong, J., Koganti, A., Zhu, H., Robbins, C., Makalowska, I., Martino, J.M., Shin, S., Marin, Y., Roberts, K. G., Yudt, L.M., Chen, A., Cheng, J., Incao, A., Pinkett, H.W., Graham, C.L., Dunn, K., Galdzicki, M., Crespo-Carbone, S.M., Mackason, K. R., Ryan, K.B., Sinsimer, D., Goydos, J., Reuhl, K. R., Eckhaus, M., Meltzer, P.S., Pavan, W.J., Trent, J.M. And Chen, S. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nature Genetics (2003) 34, 108-112.

Cohen-Solal, K., Sood, R., Marin, Y., Crespo-Carbone, S.M., Sinsimer, D., Martino, J.J., Robbins, C., Makalowska, I., Trent, J.M. And Chen, S. Identification and characterization of mouse rab 32 by mrna and protein expression analysis. Biochimica Biophysica Acta (2003) 1651, 68-75.

Marin, Y., Namkoong, J., Cohen-Solal, K., Shin, S., Martino, J., Oka, M. And Chen, S. Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates Erk1/2 via PKCe. Cell Signaling (2006) 18, 1279-1286.

Le, M. N., Chan, J. L.-K., Rosenberg, S., Nabatian, A., Merrigan, K., Cohen-Solal, K. and Goydos J. S. The glutamate release inhibitor Riluzole decreases migration, invasion and proliferation of melanoma cells. Journal of Investigative Dermatology (2010) 130, 2240-2249.

Lasfar, A. and Cohen-Solal, K. Resistance to Transforming Growth Factor-β-mediated tumor suppression in melanoma: Are multiple mechanisms in place? Carcinogenesis (2010) 31, 1710-1717.

Cohen-Solal, K.,  Merrigan, K., Chan, J. L.-K., Goydos J. S., Chen, W., Foran, D.J., Liu, F., Lasfar, A. and Reiss, M. Constitutive Smad linker phosphorylation in melanoma: A mechanism of resistance to Transforming Growth Factor-β-mediated tumor suppression. Pigment Cell Melanoma Res. (2011) 24. 512-524

Lasfar, A, Abushahba, W., Balan, M. and Cohen-Solal, K.  Interferon lambda: A new sword in cancer immunotherapy. (2011) Clinical and Developmental Immunology (2011);2011:349575. Epub 2011 Dec 6.
Abushahba, W., Olabisi, O. O., Jeong, B-S., Boregowda, R. K. , Wen, Y., Liu, F., Goydos, J. S., Lasfar, A. and Cohen-Solal, K. Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma. In Press in PLoS ONE, 2012. DOI 10.1371/journal.pone.0047312
Cohen-Solal, K., Bailly, A., Rauch, C., Quesne, M. And Milgrom, E. "Specific binding of progesterone receptor to progesterone-responsive elements does not require prior dimerization". Eur. J. Biochem. (1993) 214, 189-195.

Chauchereau, A., Cohen-Solal, K., Jolivet, A., Bailly, A. And Milgrom, E. "Phosphorylation sites in ligand-induced and ligand-independent activation of the progesterone receptor". Biochemistry (1994) 33, 14333-14338.

Cohen-Solal, K., Villeval, J. L., Titeux, M., Lok, S., Vainchenker, W. And Wendling, F. Constitutive expression of mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood (1996) 88, 2578-2584.

Cohen-Solal, K., Debili, N., Vainchenker, W. And Wendling, F. Thrombopoietin (Mpl Ligand) and the regulation of platelet production. Thrombosis And Haemostasis (1997) 78, 37-41.

Villeval, J. L., Cohen-Solal, K., Tulliez, M., Giraudier, S., Guichard, J., Burstein, S., Cramer, E., Vainchenker, W. And Wendling, F. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood (1997) 90, 4369-4383.