J. Don Chen, PhD

Professor of Pharmacology
Robert Wood Johnson Medical School

Staged Research Buidling
661 Hoes Lane West, Room 140
Piscataway, NJ 08854

Phone: (732) 235-3292
Email: chenjd@umdnj.edu

Research Program Alignment

• Non-Programmatically Aligned

Membership Type: Associate

Selected Publications

Chen, J. D. & Pirrotta, V. (1993) Multimerization of the Drosophila Zeste Protein is Required for Efficient DNA Binding. EMBO J., 12: 2075-2083.

Yao, T.-P., Forman, B.M., Jiang, Z., Cherbas, L., Chen, J. D., Mckeown, M., Cherbas, P. & Evans, R.M. (1994) The Functional and Pharmacologic Ecdysone Receptor is the Product of the ECR and Ultraspiracle Genes. Nature, 366: 476-479.

Dyck, J.A., Maul, G., Miller, W.H. Jr., Chen, J. D., Kakizuka, A. & Evans, R.M. (1994) A Novel Macromolecular Structure is a Target of the PML-RAR Oncoprotein. Cell, 76: 333-343.

Chen, J. D. & Evans, R. M. (1995) A Transcriptional Co-Repressor that Interacts with Nuclear Hormone Receptors.  Nature, 377: 454-457.

Chen, J. D. Umesono, K. & Evans, R.M. (1996) SMRT Isoforms Mediate Repression and Anti-repression of Nuclear Receptor Heterodimers. Proc. Natl. Acad. Sci. USA 93: 7567-7571.

Li, H., Gomes, P. & Chen, J.D. (1997) RAC3, a Steroid/Nuclear Receptor Coactivator that is Related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94: 8479-8484.

Park, E-J., Schroen, D.J., Yang, M., Li, H., Li, L., & Chen, J.D. (1999) SMRTe, a Silencing Mediator for Retinoid and Thyroid Hormone Receptors-extended Isoform that is More Related to the Nuclear Receptor Corepressor.  Proc. Natl. Acad. Sci. USA 96: 3519-3524.

Li, H., Leo, C., Zhu, J., Wu, X., O’Neil, J., Park, E-J. & Chen, J.D. (2000) Sequestration and Inhibition of Daxx-mediated Transcriptional Repression by PML. Mol. Cell. Biol., 20: 1784-1796.

Chisamore, M.J., Wilkinson, H.A., Flores, O., and Chen, J.D. (2009) Estrogen-related receptor-{alpha} antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenografts. Mol. Cancer Ther., 8: 672-681.

Li, C.-W., Dinh, G.K., and Chen, J.D. (2009) Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. Mol. Pharmacol., 75: 363-373.

Chisamore MJ, Cunningham ME, Flores O, Wilkinson HA, Chen JD. (2009) Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells. PLoS ONE. 4(5):e5624.

Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG. (2009) The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos. 37(6):1295-304.

Li CW, Dinh GK, Chen JD. (2009) Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. Mol Pharmacol. 75(2):363-73.

Neilsen PM, Cheney KM, Li CW, Chen JD, Cawrse JE, Schulz RB, Powell JA, Kumar R, Callen DF. (2008) Identification of ANKRD11 as a p53 coactivator. J Cell Sci. 121(Pt 21):3541-52.

Li CW, Dinh GK, Zhang A, Chen JD. (2008) Ankyrin repeats cofactors interact with ADA3 and modulate its coactivator function. Biochem J. 413(2):349-57.