Researcher Profile

Darren R. Carpizo, MD, PhD

Assistant Professor of Surgery, Surgical Oncology
Robert Wood Johnson Medical School

Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-8524
Email: carpizdr@umdnj.edu

Assistant: Carol Brodzinski
(732) 235-8524
Email: brodzica@umdnj.edu

Research Program Alignment

Membership Type: Associate - CCSG


Research Interests

  • Clinical Research Interests include: Pancreatic Cancer, Liver Cancer, Metastatic Colorectal Cancer, Biliary Cancers, Whipple Surgery, Radioembolization of Liver Tumors, and Regional Liver Chemotherapy
  • Translational/Laboratory Research Interests include: P53 Targeted Drug Development, Hedgehog Signaling in Pancreas Cancer, P53 Tumor Biology, and Mouse models of Pancreas Cancer
  • Award/Grants: AACR/Pancreatic Cancer Action Network Career Development Award 2012, and CINJ IMPACT Award 2012

Selected Publications

Gensure RH, Foran DJ, Lee VM, Gendel VM, Jabbour SK, Carpizo DR, Nosher JL, Yang L. Evaluation of Hepatic Tumor Response to Yttrium-90 Radioembolization Therapy Using Texture Signatures Generated from Contrast-enhanced CT Images. Acad Radiol. 2012 Oct;19(10):1201-7. Epub 2012 Jul 26.

Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-Specific p53 Mutant Reactivation. Cancer Cell. 2012 May 25;21(5):614-25.

Rodríguez-Manzaneque JC, Carpizo D, Plaza-Calonge Mdel C, Torres- Collado AX, Thai SN, Simons M, Horowitz A, Iruela-Arispe ML. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int J Biochem Cell Biol. 2009 Apr;41(4):800-10. Epub 2008 Aug 15.

Carpizo DR, Chandrakanth A, Jarnagin W, DeMatteo R, Fong Y,  Gönen M,  Blumgart L, and D'Angelica M.  Liver Resection for metastatic  colorectal cancer in patients with concurrent extrahepatic disease: results in 127 patients treated at a single center.  Ann Surg Oncol. 2009 Sep;16(9):2411-21. Epub 2009 Jun 25.

Lee S, Jilani SM, Nikolova GV, Carpizo DR, Iruela-Arispe ML.  Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.  Journal of Cell Biology 169(4); 681-691 (2005).

Luque, A, Carpizo, DR, Iruela-Arispe, ML.  ADAMTS-1/METH-1 inhibits endothelial cell proliferation by direct binding and sequestering ofVEGF165.  Journal of Biological Chemistry, 278(26); 23656-23665 (20003).

Iruela-Arispe ML, Carpizo DR, Luque A. ADAMTS-1:  A matrix metalloprotease with angioinhibitory properties. Ann NY Acad Sci, 995; 183-190, 2003.

Carpizo DR, ML Iruela-Arispe.  Endogenous Regulators of Angiogenesis – Emphasis on Proteins with Thrombospondin –type I Motifs.  Metallospondin Review.  Cancer Metastasis Reviews, 19; 159-165, 2000.

The content for this Research Profile is maintained by Paul Novembre (novembre@umdnj.edu)