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Edmond J. LaVoie, PhD

Selected Publications

Mavurapu Satyanarayana, Wei Feng, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, Synthesis and evaluation of suspect metabolites of 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N-dimethylamino)ethyl]dibenzo[c,h][1,6] naphthyridin-5-one, ARC-111, as a novel topoisomerase I-targeting antitumor agent, Submitted to Genzyme for Review.

Wei Feng, Mavurapu Satyanarayana, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, Comparative antitumor activity of structurally-related benzo[i]phenanthridine-11- and 12-carboxamides, 5-(2-aminoethyl)-5H-dibenzo[c,h][1,6]naphthyridin-6-ones and 6-2-(2-aminoethyl)-6H-dibenz[c,h][2,6]naphthyridin-5-ones, Submitted to Genzyme for Review.

Ajit Parhi, Yuan-chin Tsai, Angela A. Liu, Leroy F. Liu, and Edmond J. LaVoie, Synthesis and comparative biological activities of 8-hydroxy-9-methoxy-2,3-methylenedioxy-5-[2-(N,N-dimethylamino)ethyl]dibenzo[c,h]naphthyridin-6-one (8-desmethyl ARC-111) and its derivatives, Bioorg. Med. Chem. Lett., 22, 2012 Submitted to Genzyme for Review.

Gifty Blankson, Suzanne G. Rzuczek, Daniel S. Pilch, Angela Liu, Leroy Liu, Edmond J. LaVoie, and Joseph E. Rice Macrocyclic Pyridyl Polyoxazoles: Structure-activity Studies of the Aminoalkyl Side-chain on G-quadruplex Stabilization and Cytotoxic Activity, Bioorg. Med. Chem. Lett., 22, 2012 In Preparation.

Ajit Parhi, Yongzheng Zhang, Kurt W. Saionz, Malvika Kaul, Daniel S. Pilch, and Edmond J. LaVoie, Antimicrobial Activity of Quinoxalines, Quinazolines, and 1,5-Naphthyridines, Euro. J. of Med. Chem., 59, 2012 In Preparation.

Yongzheng Zhang, Daniel Giurelo, Ajit Parhi, Malvika Kaul , Daniel S. Pilch and Edmond J. LaVoie, Substituted 1,6-Diphenylnaphthalenes as Antibacterial Agents, Bioorg. Med. Chem. Lett., 22, 2012 In Preparation.

Cody Kelley, Songfeng Lu, Ajit Parhi, Malvika Kaul, Daniel S. Pilch, and Edmond J. LaVoie Antimicrobial Activity of Various 4- and 5-Substituted 1-Phenylnaphthalenes. Euro. J. of Med. Chem., 58, 2012 Submitted.

Cody Kelley, Yongzheng Zhang, Ajit Parhi, Malvika Kaul, Daniel S. Pilch, and Edmond J. LaVoie 3-Phenyl Substituted 6,7-Dimethoxyisoquinoline Derivatives as FtsZ-Targeting Antibacterial Agents. Bioog. Med. Chem., 20, 2012 Submitted.

Malvika Kaul, Ajit K. Parhi, Yongzheng Zhang, Edmond J. LaVoie, Steve Tuske,| Eddy Arnold, John E. Kerrigan, and Daniel S. Pilch A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization, J. Med. Chem., 55, 2012, In Press.

Ajit Parhi, Cody Kelley, ,Malvika Kaul, Daniel S. Pilch, and Edmond J. LaVoie, Antibacterial Activity of Substituted 5-Methylbenzo[c]phenanthridinium Derivatives Bioorg. Med. Chem. Lett., 22, 2012 In Press.

Ajit Parhi, Songfeng Lu, Cody Kelley , Malvika Kaul, Daniel S. Pilch and Edmond J. LaVoie, Antibacterial Activity of Substituted Dibenzo[a,g]quinolizin-7-ium Derivatives. Bioorg. Med. Chem. Lett., 22, 2012 In Press.

Leslie S. Kurtzberg, Stephanie Roth, Roy Krumbholz, Jennifer Crawford, Christy Bormann, Min Yao, Rebecca G. Bagley, Xian-Jie Yu, Fei Wang, Steven M. Schmid, Edmond J. LaVoie, Beverly A. Teicher, Genz-644282, a Novel Non-Camptothecin Topoisomerase I inhibitor for Cancer Treatment, Clinical Cancer Research, 17, 2011, 2777-87.

Suzanne G. Rzuczek, Daniel S. Pilch, Angela Liu, Leroy Liu, Edmond J. LaVoie, and Joseph E. Rice, Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents, J. Med. Chem., 53, 3632-3644, 2010.

Mavurapu Satyanarayana,Young-Ah Kim , Suzanne G. Rzuczek, Daniel S. Pilch, Angela A. Liu, Leroy F. Liu, Joseph E. Rice and Edmond J. LaVoie, Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity, Bioorg. Med. Chem. Lett., 20, 3150-3154, 2010.

Mavurapu Satyanarayana, Suzanne G. Rzuczek, Edmond J. LaVoie, Daniel S. Pilch, Angela Liu, Leroy F. Liu and Joseph E. Rice, Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency, Bioorg. Med. Chem. Lett., 18, 3802-3804, 2008.

Daniel S. Pilch, Christopher M. Barbieri, Suzanne G. Rzuczek, Edmond J. LaVoie and Joseph E. Rice, Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds, Biochimie, 90, 1233-1249, 2008.

Leslie S. Kurtzburg, Traci Battle, Cecile, Rouleau, Rebecca G. Bagley, Naoki, Agata, Min Yao, Steven Schmidt, Stephanie Roth, Jennifer Crawford, Roy Krumbholtz, Reginald Ewesuedo, Xian-Jie Yu, Fei Wang, Edmond J. LaVoie and Beverley A. Teicher, Bone marrow and tumor cell CFU and human xenograft efficacy of non-camptothecin and camptothecin topoisomerase I inhibitors, Mol. Cancer Ther., 7, 3212-3222, 2008.

Yuan-Chin Tsai, Haiyan Qi, Chao-Pao Lin, Edmond J. LaVoie, Joseph E. Rice, Daniel S. Pilch, and Leroy F. Liu, Induction of M Phase Arrest and Apoptosis by a Novel G-Quadruplex Stabilizer, J. Biol. Chem., 284, 22535-22543, 2009

Wei Feng, Mavurapu Satyanarayana, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo-[i]phenanthridine derivatives as novel topoisomerase I-targeting antitumor agents, Bioorg. Med. Chem., 17, 2877-2885, 2009.

Wei Feng, Mavurapu Satyanarayana, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6] naphthyridin-5-one, European J. Med. Chem. 44, 3433-3438, 2009.

Lisa Sharma, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, Evaluation of the Cytotoxicity and TOP1-Targeting Activity of 8-and 9-Amino Derivatives of 5-Butyl-5H-dibenzo[c,h][1,6]naphthyridin-6-one and 5-(2-N,N-Dimethyl-amino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-one, Euro. J. of Med. Chem., 44, 1471-1476, 2009.