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TJ Thomas, PhD

Selected Publications

  1. Vijayanathan, V., Venkiteswaran, S., Nair, S.K., Verma, A., Thomas, T.J., Zhu, B.T., and Thomas, T. (2006) Physiological levels of 2-methoxyestradiol interfere with nongenomic signaling of 17β-estradiol in human breast cancer cells. Clin. Cancer Res. 12, 2038-2048. PMID: 16609013
  2. Nair, S.K., Verma, A., Thomas, T.J., Chou, T.C., Gallo, M.A., Shirahata, A., Thomas, T. (2007) Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett. 250:311-322. PMCID: PMC1899838
  3. John, S., Nayvelt, I., Hsu, H.C., Yang, P., Liu, W., Das, G.M., Thomas, T., and Thomas, T.J. (2008) Regulation of estrogenic effects by beclin 1 in breast cancer cells. Cancer Res. 68, 7855-7863. PMID: 18829541
  4. Bourassa, P., Dubeau, S., Maharvi, G.M., Fauq, A.H., Thomas, T.J., Tajmir-Riahi, H.A. (2011) Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. Eur. J. Med. Chem. 46:4344-53. PMID: 21777996
  5. Bourassa, P., Thomas, T.J., Tajmir-Riahi, H.A. (2014) Locating the binding sites of antitumor drug tamoxifen and its metabolites with DNA. J. Pharm. Biomed. Anal. 95:193-199. PMID: 24682017
  6. Thomas, T. and Thomas, T.J. (1994) Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. Breast Cancer Res. Treat. 29:189-201. PMID: 8012036
  7. Thomas, T., and Thomas, T.J. (1994) Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells. Cancer Res. 54:1077-1084. PMID: 8313364
  8. Thomas, T.J., Faaland, C.A., Adhikarakunnathu, S., Watkins, L.F., and Thomas, T. (1998) Induction of p21 (CIP1/WAF1/SID1) by estradiol in a breast epithelial cell line transfected with the recombinant estrogen receptor gene: a possible mechanism for a negative regulatory role of estradiol. Breast Cancer Res. Treat. 47:181-193. PMID: 9497106
  9. Shah, N., Antony, T., Haddad, S., Amenta, P., Shirahata, A., Thomas, T.J., and Thomas, T. (1999) Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice. Cancer Lett. 146:15-23. PMID: 10656605
  10. Faaland, C.A., Thomas, T.J., Balabhadrapathruni, S., Langer, T., Mian, S., Shirahata, A., Gallo, M.A., Thomas, T. (2000) Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis. Biochem. Cell Biol. 78:415-426. PMID: 11012080
  11. Thomas, T., and Thomas, T.J. (2001) Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell. Mol. Life Sci. 58:244-258. PMID: 11289306
  12. Shah, N., Thomas, T.J., Lewis, J.S., Klinge, C.M., Shirahata, A., Gelinas, C., and Thomas, T. (2001) Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells. Oncogene 20:1715-1729. PMID: 11313919
  13. Lewis, J.S., Thomas, T.J., Klinge, C.M., Gallo, M.A., and Thomas, T. (2001) Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. J. Mol. Endocrinol. 27:293-307. PMID: 11719282
  14. Lewis, J.S., Vijayanathan, V., Thomas, T.J., Pestell, R.G., Albanese, C., Gallo, M.A., and Thomas, T. (2005) Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. Oncol Res. 15:113-128. PMID: 16050133
  15. Bourassa, P., Dubeau, S., Maharvi, G.M., Fauq, A.H., Thomas, T.J., and Tajmir-Riahi, H.A. (2011) Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin. Biochimie 93:1089-1101. PMID: 21439346