NJMS-UH Cancer Center
205 South Orange Avenue, G1218
Newark, NJ 07103
Investigating the Rb/E2F pathway and other tumor suppressor/oncogenic pathways control normal development and cancer. Both in vitro cell/tissue culture systems and in vivo mouse models are used to delineate various signaling networks in several model systems: 1) to investigate whether the hematopoietic defects identified in mice with Rb-deficient hematopoeitic stem cells is dependent on E2F function, and whether loss of Rb and other Rb family members is sufficient to induce leukemias or lymphomas
2) to identify early cellular and molecular responses to activation of Myc or ErbB2 oncogenes and to deletion of E2Fs in mammary epithelial cells
3) to investigate the in vivo role of E2Fs on Myc-triggered prostate cancer initiation or progression
And 4) to determine whether the ErbB2/Ras signaling network is involved in prostate androgen-independent transition and/or metastasis of Myc-triggered prostate cancers. Our studies will not only provide critical insights on how various tumor suppressor and oncogenic signaling pathways function and interact, but may also lead to improved cancer diagnosis, prognosis, and molecule- or pathway-based cancer therapies.