Cancer Prevention Studies at CINJ
Prevention research studies are designed to answer important questions about the early detection and prevention of cancer. Detecting and eliminating pre-cancerous cells increases our ability to prevent cancer from ever forming. Several prevention research studies are on-going at The Cancer Institute of New Jersey. You can be an important part of our program to prevent cancer by participating in one of these research studies: Mouth Cancer: A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Researchers at The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School and New Jersey Dental School are seeking participants for a study investigating green tea as a potential agent in the treatment of leukoplakia, a pre-malignant lesion of the mouth that often precedes oral cancer. Lozenges containing green tea will be taken by participants eight times per day for twelve weeks to see if the leukoplakia lesions get smaller. If you have oral leukoplakia lesions, you may be eligible to participate in this study. Prostate Cancer: Randomized Phase II Trial of Calcitriol in Patients with Prostatic Intraepithelial Neoplasia (PIN) The Cancer Institute of New Jersey is conducting a study of new treatments for men who have a genetic and morphologic precursor to prostate cancer called high-grade prostatic intraepithelial neoplasia, or simply PIN. Currently, there is no prevention regimen against PIN. However, recent clinical data demonstrates that Calcitriol, a Vitamin D derivative, can be effective in protecting against prostate cancer. This study will look at the effects of Calcitriol on PIN, and track the Prostate Specific Antigen (PSA) during the course of treatment. The study lasts approximately 32 weeks and eligible participants cannot have been previously diagnosed with prostate cancer. Prostate Cancer: A Randomized Phase I Study to Investigate the Presence of Green Tea Metabolites in the Prostate In laboratory tests, green tea has been shown to protect against several cancers. This study will look at whether ingredients in green tea can be detected in prostate tissue in patients that have been referred for surgery. Lung Cancer: Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage One Non-Small Cell Lung Cancer Have you or someone you know had lung cancer? Studies have shown that patients who have had lung cancer are at an increased risk of developing another new lung cancer, even if the first was successfully removed. If you’ve had surgery for stage 1 non-small cell lung cancer within the last 3 years, and are over the age of 18, you may be able to help. A nationwide clinical research trial is underway to see if second lung cancers can be prevented. The trial focuses on patients who have already been treated for stage 1 non-small cell lung cancer and is designed to see if taking a selenium supplement, a mineral found in foods, can reduce the occurrence of new lung tumors in patients who are prone to developing second cancers. Gastrointestinal Cancer: Studies of Esophageal Metaplasia Using a Novel Antibody Do you have chronic acid reflux, heartburn or indigestion? Acid reflux can, over time, cause damage to the white lining of the esophagus, replacing it with an abnormal red lining called Barrett’s Esophagus (BE). Over time, BE can develop into esophageal cancer. A study now being conducted at CINJ and RWJUH is designed to detect people who may develop BE, in the hopes of ultimately preventing the onset of esophageal cancer. Participants must have symptoms related to acid reflux and it must be at least one year since their last upper endoscopy. Patients who show signs of being susceptible to BE may also be eligible for a prevention study upon completion of the acid reflux study.
If you would like information about clinical trials being conducted at The Cancer Institute of New Jersey, please call 1-866-654-9898. If you would like further information about clinical trials available in New Jersey for preventing cancer, please call New Jersey Cancer Trial Connect at 1-1-866-788-3929 or visit the Web site at www.njctc.org. For additional information about nationwide cancer prevention trials, you can also call the National Cancer Institute at 1-800-4 CANCER or visit their Web site at www.cancer.gov. |
