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Pine Laboratory - Select Publications

Mitchell K, Nichols N, Tang W, Walling J, Stevenson H, Pineda M, Stefanescu R, Edelman DC, Girvin AT, Zingone A, Sinha S, Bowman E, Rossi E, Arauz R, Zhu YJ, Weingartner E, Waterfall J, Simmons J, Meltzer P, Pine SR, Ryan BM, *Co-corresponding authors. Recurrent PTPRD/PTPRT and JAK2 Mutations in Lung Adenocarcinoma among African Americans. In press, 2019. Nature Communications. Forthcoming;

Garbuzenko OB, Kuzmov A, Taratula O, Pine SR, Minko T. Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy. Theranostics. 2019 October; 9(26):8362-8376.

Epsi NJ, Panja S, Pine SR, Mitrofanova A. pathCHEMO, a generalizable computational framework uncovers molecular pathways of chemoresistance in lung adenocarcinoma. Commun Biol. 2019;2:334. doi: 10.1038/s42003-019-0572-6. eCollection 2019. PubMed PMID: 31508508; PubMed Central PMCID: PMC6731276.

Mitchell KA, Shah E, Bowman ED, Zingone A, Nichols N, Pine SR, Kittles RA, Ryan BM. Relationship between West African ancestry with lung cancer risk and survival in African Americans. Cancer Causes Control. 2019 Aug 29;. doi: 10.1007/s10552-019-01212-z. [Epub ahead of print] PubMed PMID: 31468279.

Meaney CL, Mitchell KA, Zingone A, Brown D, Bowman E, Yu Y, Wenzlaff AS, Neslund-Dudas C, Pine SR, Cao L, Schwartz AG, Ryan BM. Circulating Inflammation Proteins Associated With Lung Cancer in African Americans. J Thorac Oncol. 2019 Jul;14(7):1192-1203. doi: 10.1016/j.jtho.2019.03.014. Epub 2019 Apr 3. PubMed PMID: 30953795; PubMed Central PMCID: PMC6592767.

Castellano GM, Aisner J, Burley SK, Vallat B, Yu HA, Pine SR, Ganesan S. A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib: a Brief Report. J Thorac Oncol. 2019 Jun 26;. doi: 10.1016/j.jtho.2019.06.015. [Epub ahead of print] PubMed PMID: 31254668.

Pine SR. Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target?. Clin Cancer Res. 2018 Dec 15;24(24):6136-6141. doi: 10.1158/1078-0432.CCR-18-1635. Epub 2018 Aug 13. PubMed PMID: 30104200; PubMed Central PMCID: PMC6295228.

Pine SR, Sabaawy HE. Editorial: Harnessing the Power of Patient Derived Models of Cancer. Front Oncol. 2018;8:349. doi: 10.3389/fonc.2018.00349. eCollection 2018. PubMed PMID: 30237982; PubMed Central PMCID: PMC6135905.

Pine SR, Ryan BM. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018 Sep;7(Suppl 3):S265-S269. doi: 10.21037/tlcr.2018.09.10. PubMed PMID: 30393619; PubMed Central PMCID: PMC6193905.

Patrizii M, Bartucci M, Pine SR, Sabaawy HE. Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy. Front Oncol. 2018;8:23. doi: 10.3389/fonc.2018.00023. eCollection 2018. PubMed PMID: 29484285; PubMed Central PMCID: PMC5816058.

Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol Cancer Ther. 2017 Dec;16(12):2759-2769. doi: 10.1158/1535-7163.MCT-17-0439. Epub 2017 Oct 4. PubMed PMID: 28978720; PubMed Central PMCID: PMC5716926.

Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma. Clin Cancer Res. 2017 Sep 15;23(18):5631-5638. doi: 10.1158/1078-0432.CCR-16-0758. Epub 2017 May 24. PubMed PMID: 28539463.

Morgan KM, Riedlinger GM, Rosenfeld J, Ganesan S, Pine SR. Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer and Their Potential Utility in Personalized Medicine. Front Oncol. 2017;7:2. doi: 10.3389/fonc.2017.00002. eCollection 2017. PubMed PMID: 28154808; PubMed Central PMCID: PMC5243815.

Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. doi: 10.1093/nar/gkw748. Epub 2016 Aug 26. PubMed PMID: 27566146; PubMed Central PMCID: PMC5062998.

Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC. Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans. Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):488-97. doi: 10.1158/1055-9965.EPI-15-0378. Epub 2015 Dec 28. PubMed PMID: 26711330; PubMed Central PMCID: PMC4779723.

Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC. Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. Cancer Res. 2015 Feb 1;75(3):566-75. doi: 10.1158/0008-5472.CAN-14-2101. Epub 2014 Dec 5. PubMed PMID: 25480945; PubMed Central PMCID: PMC4315715.

Ryan BM, Pine SR, Chaturvedi AK, Caporaso N, Harris CC. A combined prognostic serum interleukin-8 and interleukin-6 classifier for stage 1 lung cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Thorac Oncol. 2014 Oct;9(10):1494-503. doi: 10.1097/JTO.0000000000000278. PubMed PMID: 25170636; PubMed Central PMCID: PMC4272608.

Pine SR, Liu W. Asymmetric cell division and template DNA co-segregation in cancer stem cells. Front Oncol. 2014;4:226. doi: 10.3389/fonc.2014.00226. eCollection 2014. Review. PubMed PMID: 25191642; PubMed Central PMCID: PMC4139651.

Liu W, Morgan KM, Pine SR. Activation of the Notch1 Stem Cell Signaling Pathway during Routine Cell Line Subculture. Front Oncol. 2014;4:211. doi: 10.3389/fonc.2014.00211. eCollection 2014. Review. PubMed PMID: 25147757; PubMed Central PMCID: PMC4123601.

Capaccione KM, Hong X, Morgan KM, Liu W, Bishop JM, Liu L, Markert E, Deen M, Minerowicz C, Bertino JR, Allen T, Pine SR. Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget. 2014 Jun 15;5(11):3636-50. doi: 10.18632/oncotarget.1970. PubMed PMID: 25004243; PubMed Central PMCID: PMC4116509.

Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest. 2013 Dec;123(12):5247-57. doi: 10.1172/JCI70355. Epub 2013 Nov 15. PubMed PMID: 24231352; PubMed Central PMCID: PMC3859419.

Liu W, Jeganathan G, Amiri S, Morgan KM, Ryan BM, Pine SR. Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines. Mol Cancer. 2013 Nov 15;12(1):139. doi: 10.1186/1476-4598-12-139. PubMed PMID: 24238140; PubMed Central PMCID: PMC3866575.

Capaccione KM, Pine SR. The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis. 2013 Jul;34(7):1420-30. doi: 10.1093/carcin/bgt127. Epub 2013 Apr 12. Review. PubMed PMID: 23585460; PubMed Central PMCID: PMC3697894.

Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC. MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. Int J Cancer. 2012 Dec 1;131(11):2710-6. doi: 10.1002/ijc.27573. Epub 2012 Apr 27. PubMed PMID: 22487911; PubMed Central PMCID: PMC3414691.

Patel SA, Ramkissoon SH, Bryan M, Pliner LF, Dontu G, Patel PS, Amiri S, Pine SR, Rameshwar P. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci Rep. 2012;2:906. doi: 10.1038/srep00906. Epub 2012 Nov 30. PubMed PMID: 23205268; PubMed Central PMCID: PMC3510468.

Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE, Harris CC. Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst. 2011 Jul 20;103(14):1112-22. doi: 10.1093/jnci/djr216. Epub 2011 Jun 17. PubMed PMID: 21685357; PubMed Central PMCID: PMC3139587.

Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM. Admixture mapping of lung cancer in 1812 African-Americans. Carcinogenesis. 2011 Mar;32(3):312-7. doi: 10.1093/carcin/bgq252. Epub 2010 Nov 29. PubMed PMID: 21115650; PubMed Central PMCID: PMC3047238.

Chaturvedi AK, Caporaso NE, Katki HA, Wong HL, Chatterjee N, Pine SR, Chanock SJ, Goedert JJ, Engels EA. C-reactive protein and risk of lung cancer. J Clin Oncol. 2010 Jun 1;28(16):2719-26. doi: 10.1200/JCO.2009.27.0454. Epub 2010 Apr 26. PubMed PMID: 20421535; PubMed Central PMCID: PMC2881850.

Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2195-200. doi: 10.1073/pnas.0909390107. Epub 2010 Jan 13. PubMed PMID: 20080668; PubMed Central PMCID: PMC2836660.

Olivo-Marston SE, Yang P, Mechanic LE, Bowman ED, Pine SR, Loffredo CA, Alberg AJ, Caporaso N, Shields PG, Chanock S, Wu Y, Jiang R, Cunningham J, Jen J, Harris CC. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83. doi: 10.1158/1055-9965.EPI-09-0986. PubMed PMID: 19959685; PubMed Central PMCID: PMC2951599.

Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol. 2009 Sep;11(9):1135-42. doi: 10.1038/ncb1928. Epub 2009 Aug 23. PubMed PMID: 19701195; PubMed Central PMCID: PMC2802853.

Martin RC, Barker DF, Doll MA, Pine SR, Mechanic L, Bowman ED, Harris CC, Hein DW. Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population. DNA Cell Biol. 2008 Jun;27(6):321-3. doi: 10.1089/dna.2007.0725. PubMed PMID: 18466086; PubMed Central PMCID: PMC2576292.

Pine SR, Marshall B, Varticovski L. Lung cancer stem cells. Dis Markers. 2008;24(4-5):257-66. doi: 10.1155/2008/396281. Review. PubMed PMID: 18525120; PubMed Central PMCID: PMC3850541.

Pine SR, Mechanic LE, Ambs S, Bowman ED, Chanock SJ, Loffredo C, Shields PG, Harris CC. Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J Natl Cancer Inst. 2007 Sep 19;99(18):1401-9. doi: 10.1093/jnci/djm128. Epub 2007 Sep 11. PubMed PMID: 17848669; PubMed Central PMCID: PMC6278934.

Pine SR, Guo Q, Yin C, Jayabose S, Druschel CM, Sandoval C. Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. Blood. 2007 Sep 15;110(6):2128-31. doi: 10.1182/blood-2007-01-069542. Epub 2007 Jun 18. PubMed PMID: 17576817.

Sabaawy HE, Sandoval C, Guo Q, Yin C, Kulangara A, Lee J, Wormser G, Jayabose S, Pine SR. Lymphoproliferative clonal origin of AIDS-related non-Hodgkin's lymphoma. Leuk Lymphoma. 2007 Apr;48(4):812-5. doi: 10.1080/10428190601173109. PubMed PMID: 17454643.

Sandoval C, Pine SR. Down syndrome and GATA1-related transient leukemia. J Pediatr. 2007 Mar;150(3):e34. doi: 10.1016/j.jpeds.2006.10.055. PubMed PMID: 17307526.

Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Pine S, Sandoval C. A Case of Relapsed Down Syndrome–Associated Acute Megakaryoblastic Leukemia Cured with Non-Myeloablative Chemotherapy. Clinical Leukemia. 2007; 1:309 - 312. doi: 10.3816/CLK.2007.n.023.

Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG, Harris CC. MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1559-61. doi: 10.1158/1055-9965.EPI-06-0217. PubMed PMID: 16896050.

Pine SR, Guo Q, Yin C, Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C. GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome. Leuk Res. 2005 Nov;29(11):1353-6. doi: 10.1016/j.leukres.2005.04.007. PubMed PMID: 15916804.

Pine SR, Yin C, Matloub YH, Sabaawy HE, Sandoval C, Levendoglu-Tugal O, Ozkaynak MF, Jayabose S. Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. J Mol Diagn. 2005 Feb;7(1):127-32. doi: 10.1016/S1525-1578(10)60018-9. PubMed PMID: 15681484; PubMed Central PMCID: PMC1867497.

Sandoval C, Pine SR, Guo Q, Sastry S, Stewart J, Kronn D, Jayabose S. Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature. Pediatr Blood Cancer. 2005 Jan;44(1):85-91. doi: 10.1002/pbc.20161. Review. PubMed PMID: 15390279.

Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S. Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Polymerase chain reaction. J Pediatr Hematol Oncol. 2003 Feb;25(2):103-8. doi: 10.1097/00043426-200302000-00004. PubMed PMID: 12571459.

Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leuk Res. 2003 Feb;27(2):155-64. doi: 10.1016/s0145-2126(02)00183-2. PubMed PMID: 12526921.

Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15101-6. doi: 10.1073/pnas.222481199. Epub 2002 Nov 1. PubMed PMID: 12415113; PubMed Central PMCID: PMC137550.

Mayer SP, Jayabose S, Tugal O, Ozkaynak MF, Rosenblum-Vos L, Sandoval C. Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia. Leuk Lymphoma. 2002 Sep;43(9):1881-4. doi: 10.1080/1042819021000006349a. PubMed PMID: 12685849.

Senzaki H, Smith CJ, Juang GJ, Isoda T, Mayer SP, Ohler A, Paolocci N, Tomaselli GF, Hare JM, Kass DA. Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J. 2001 Aug;15(10):1718-26. doi: 10.1096/fj.00-0538com. PubMed PMID: 11481219.

Deptala A, Mayer SP. Detection of minimal residual disease. Methods Cell Biol. 2001;64:385-420. doi: 10.1016/s0091-679x(01)64023-8. PubMed PMID: 11070849.

Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M. Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2000 Nov;29(3):219-28. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1028>3.0.co;2-d. PubMed PMID: 10992297.

Sandoval C, Mayer SP, Giamelli J, Farley T, Ozkaynak MF, Tugal O, Jayabose S. Cytogenetic abnormalities during clinical, immunophenotypic, and molecular remission in pediatric acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2000 Apr 1;118(1):9-13. doi: 10.1016/s0165-4608(99)00161-2. PubMed PMID: 10731583.

 

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